![]() ![]() In ovary, depletion of MTA3 suppresses cell proliferation via inhibition of cell cycle progression and blocking M phase entry and thus functions in granulose cell proliferation. In mammary gland development, MTA3 plays a fundamental role in regulating the differentiation of B Lymphocytes by inhibiting BCL-6 which is a transcriptional repressor and regulates the fate of B lymphocyte. MTA3 participates in primitive hematopoiesis and prevents hematopoietic and immune disorders. In brain, MTA3 helps in the development of the nervous system, acts as a tumor suppressor and prevents Alzheimer’s disease. Under normal expression and physiological conditions MTA3 regulates growth and functions of various tissues and organs. Regulatory roles of MTA3 in normal development and cancers. Infect, MTA3 may act as a tumor suppressor as well as oncogene.įig. MTA3 plays crucial role both in physiological and pathological contexts by interacting with many proteins. ![]() MTA3 interact with DNA and serve as a transcription cofactor by making complex with NuRD. MTA3 contains the bromo-adjacent homology domain (BAH domain), which mediates protein-protein interactions the SANT (SWI, ADA2, NCoR, and TFIIIBB) domain important for the formation of Mi2-NuRD complex and the ELM domain responsible for embryonic patterning (Fig. The smaller isoform MTA3 (MTA3S) is more abundant at both mRNA and protein levels. ![]() Currently, seven different MTA3 splicing variants have been reported. ![]() Structurally, MTA3 gene consists of 20 exons and binding sites to different transcriptional factors including SP1, AP1, and ER in its promoter regions. MTA3 is a 60 kDa protein expressed by the human MTA3 gene localized in chromosome 2p21. MTA3 in NuRD complex binds to the gene promoter and represses or inhibit the expression of Snail, ZEB2 proteins responsible for E-cadherin repression and induction of EMT and metastasis. A) Structure of MTA3 Protein and B) its interaction in NuRD Transcriptional Complex. ![]()
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